Summary and Speculations -- Chapter 13 Epimutations, Chromatin Disorders and Sex Differences in Phenotype -- 13. This important and enjoyable book should be read by physicians who care for women of all ages. As a consequence, most X-linked mutations produce male-only diseases. Females are Mosaics will be valuable to geneticists, biologists, and all health professionals interested in women's health. Summary and Speculations -- Chapter 12 Mosaicism -- 12. Summary and Speculations Chapter 7 Theme 2: Subsequent Steps-Spreading and Maintaining Inactivation 7. Polyploidy and the Choice of Active X 11.
The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows. Discussing the medical consequences of X inactivation and effects on individuals with chromosome abnormalities the author molecular mechanisms for chromosome inactivation and addresses the evolutionary origins of human sex chromosomes. The Dynamic Effect of Interacting Cell Populations on the Health of Females 14. Variations on the Themes of X Inactivation ; 8. She was the founding director of the Hopkins PhD Program in Human Genetics. Skewing of X Inactivation Patterns -- 12. Assays for X Inactivation Patterns in Heterozygotes -- 5.
Bibliography Includes bibliographical references p. Therefore, sex differences in the expression of these genes are likely to underlie many sex differences in the expression of diseases affected by these genes. Mouse Embryonic Stem Cells for Manipulating the Early Steps in X Inactivation -- 5. Effect of X Inactivation on Clinical Phenotype -- 12. Summary and Speculations -- Chapter 4 The Discovery of X Chromosome Inactivation -- 4.
Evolution and Tinkering ; 10. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Transient X Inactivation in Germ Cells ; 7. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease - and this new edition reflects research advances from the six years since the widely praised first edition. These results indicate that early androgen spared both androgen-sensitive and -insensitive motoneurons from cell death, confirming a site of androgen action other than the motoneurons themselves. Determinants of Female Phenotypes Other Titles: X inactivation and sex differences in disease Responsibility: Barbara R. The E-mail message field is required.
General Scheme of Mammalian Dosage Compensation -- 4. On the other hand, cellular mosaicism created by X inactivation provides a biologic advantage to females. Often, cell mosaicism is advantageous, ameliorating the deleterious effects of X-linked mutations and contributing to physiological diversity. Escape from Inactivation ; 7. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.
This book describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women. At every age, males have a higher risk of mortality than do females. Divergence in the Physical Map -- 8. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women. .
Divergence in the Physical Map ; 8. Degeneration of the Y Chromosome 2. Summary and Speculations -- Chapter 7 Theme 2: Subsequent Steps-Spreading and Maintaining Inactivation -- 7. Females Are Mosaics ; 12. Medical Consequences of X Inactivation -- Chapter 11 The Single Active X -- 11. The X-Linked Phenotype Is Dominant at the Cellular Level -- 12.
Summary and Speculations -- Chapter 10 Variations 3: Choice of Active X -- 10. The Lyon Hypothesis ; 4. Primary Nonrandom X Inactivation ; 10. Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Heterochromatin and Chromosome Silencing 3. Summary and Speculations ; Chapter 12 Mosaicism ; 12.
The Effect of Map Changes on X Inactivation in Mouse and Man ; Chapter 9 Variations 2: Stability of the Inactive X ; 9. Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Transient X Inactivation in Germ Cells 7. She was the founding director of the Hopkins PhD Program in Human Genetics. Much has been written about the Y chromosome and its role in inducing maleness.